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Congressionally Directed Medical Research Programs -- Duchenne Muscular Dystrophy Research Program -- Career Development Award
The DMDRP Career Development Award mechanism supports early-career investigators in conducting impactful Duchenne research under the mentorship of an experienced muscular dystrophy researcher as an opportunity to obtain the funding, mentoring, and experience necessary for productive, independent careers at the forefront of Duchenne research. Applicants should also demonstrate that the proposed research has high potential to lead to or make breakthroughs in Duchenne.
- Pre-Application Submission Deadline: Nov. 14, 2018
- Application Submission Deadline: Dec. 5, 2018
Areas of Interest
All applications for the FY18 DMDRP funding opportunities must address at least one of the following Focus Areas:
• Bone, cardiac, central nervous system (CNS), and/or gastrointestinal tract studies, including identifying mechanisms of pathology and therapeutic interventions
• Translational and clinical studies, novel interventions, and drug and biologic delivery technologies designed to improve care and quality of life in areas such as: ○ Cognitive function ○ Endocrinology ○ Gastrointestinal issues ○ Immunology ○ Orthopaedics ○ Psychosocial issues ○ Pulmonology (including sleep-focused studies) ○ Skeletal muscle
• Assessment of clinical trial tools and outcome measures, such as: ○ Discovery and qualification of pharmacodynamic, prognostic, and predictive biomarkers ○ Novel clinical outcome assessment ○ Patient-centered outcomes (e.g., quality of life, activities of daily living) ○ Potential surrogate markers ○ Secondary data analysis that helps to address clinical research tool validation and/or to understand natural history
• Extension or expansion of existing preclinical translational data in support of a specific therapeutic development path (such as optimizing delivery to target tissues, including drug exposure, independent replication, and comparative studies)
• Principal Investigator ○ The PI must be an independent, early-career research- or physician-scientist with a PhD, MD, or equivalent, at least 2 years post terminal degree at the time of application submission (excluding time spent in residency or on family medical leave), and exhibit a strong desire to pursue a career in Duchenne research. Physician-scientists must have clinical duties and/or responsibilities. ○ Institutional commitment to the PI’s independent career should be demonstrated, including a confirmation of the laboratory space, and at least 30% of protected time for Duchenne research. ○ The PI must not have received more than $300,000 in total direct costs (cumulative) for previous or concurrent muscular dystrophy research as a PI of one or more Federally or privately funded, non-mentored, peer-reviewed grants.
• Mentor ○ The Mentor must hold a position at or above the level of an Associate Professor (or equivalent). ○ The Mentor must be an experienced researcher as demonstrated by a strong record of funding and publications in muscular dystrophy research. The Mentor must demonstrate a commitment to developing the PI’s career in Duchenne research.
The PI and the Mentor do not need to be located at the same organization.
An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.
The anticipated direct costs budgeted for the entire period of performance for an FY18 DMDRP Career Development Award will not exceed $275,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information