Congressionally Directed Medical Research Programs -- Hearing Restoration Research Program -- Focused Research Award

Funding Agency:
Department of Defense

The FY22 HRRP FRA mechanism is intended to support promising research that accelerates drug discovery and therapeutic development for hearing restoration after military-relevant auditory system injury or accelerates advances in diagnosis of auditory dysfunction in austere environments.

Applicants are encouraged to leverage resources and expertise at the National Center for Advancing Translational Sciences (NCATS) to improve efficiency and accelerate the translational process. A list of NCATS programs and resources supporting preclinical innovation can be found at

Applications involving multidisciplinary collaborations among academia, industry, the military Services, the VA, and other federal government agencies are highly encouraged.

 Funding Levels: The FY22 HRRP FRA may be used to support preclinical studies in animals and/or clinical research involving human subjects and human anatomical substances. To support research projects at different stages and the exploration/development of ideas of different maturity levels, three funding levels are available under this program announcement. When submitting the pre-application, it is the responsibility of the applicant to select the funding level that is most appropriate for the research proposed. The funding level should be selected based on the stage and maturity level of the research project, rather than the amount of the budget.

Funding Level 1 supports exploratory, high-risk/high-reward research that is in the earliest stages of idea development. Research must have the potential to yield new avenues of investigation, such as new approaches, new research tools, or new paradigms.

Funding Level 2 supports the advancement of more mature research toward clinical translation.

Funding Level 3 supports translational research that includes a Pilot Clinical Trial (PCT).

• Required Pre-Application Deadline: July 22, 2022
• Application Submission Deadline:  November 30, 2022

Agency Website

Areas of Interest

To meet the intent of the award mechanism, all applications to the FY22 HRRP Focused Research Award (FRA) must address research in one or more of the following Focus Areas:

  • Accelerate translation of biological regeneration/repair mechanisms into therapies that treat auditory system injury and restore auditory function. For example, but not limited to: ○ Hair cell regeneration/repair/recovery ○ Neural regeneration/repair/recovery ○ Treatment for synaptopathy and hidden hearing loss
  • Diagnostic tests that help differentiate sensory, neural, synaptic, and central processing disorders, that may inform applicability and outcomes for current or future hearing restoration therapeutics.
  • Develop reliable in-vitro human models to facilitate the understanding, derivation, and characterization of human auditory cells, and/or to facilitate the evaluation of hearing restoration therapies.  
  • Develop and/or validate techniques/methods beyond the audiogram to diagnose acute auditory system injury in austere or remote environments. For example, but not limited to, simple and rapid assessments that are compatible with portable platforms.

Eligibility Requirements

Independent investigators at all academic levels (or equivalent) are eligible to be named by the recipient organization as Principal Investigator (PI) on the applications. An eligible Principal Investigator (PI), regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.

Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY22 HRRP FRA – Funding Level 1 will not exceed $250,000. The anticipated direct costs budgeted for the entire period of performance for an FY22 HRRP FRA – Funding Level 2 will not exceed $1,000,000. The anticipated direct costs budgeted for the entire period of performance for an FY22 HRRP FRA - Funding Level 3 will not exceed $1,250,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty
Medical Fellow/Resident
Post Doctoral Fellows


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

July 22, 2022