Congressionally Directed Medical Research Programs -- Joint Program Committee 8/ Clinical and Rehabilitative Medicine Research Program -- Regenerative Medicine Focused Research Award (AFIRM III)

Funding Agency:
Department of Defense

The JPC-8/CRMRP RMFRA mechanism is intended to optimize research supporting the development of technical capabilities and solutions through collaborative partnerships and synergistic projects that inform and build on each other to accelerate regenerative medicine solutions and technical capabilities that repair, reconstruct, or regenerate tissue lost or damaged due to traumatic injury. The goal of the focused research to be funded under this award mechanism is to position the most promising solutions and technical capabilities (i.e., material or knowledge products) for advanced development and ultimately for transition to medical use and/or commercialization. Therefore, products resulting from the proposed focused research must have the potential for commercialization or adoption by clinicians as surgical and/or therapeutic options. Given the complex nature of peripheral nerve and skeletal muscle regeneration, it is anticipated that the most effective solutions will involve a multifaceted approach spanning both Focus Areas and several Areas of Encouragement.


• Required Pre-Application Deadline: August 7, 2019

• Application Submission Deadline: November 20, 2019

Agency Website

Areas of Interest

To meet the intent of the award mechanism, all projects submitted under the FY19 JPC-8/ CRMRP RMFRA must address one or both of the following Focus Areas:

• Peripheral nerve regeneration

• Skeletal muscle regeneration

Efforts to regenerate peripheral nerve should focus on restoring maximal function. The goal for peripheral nerve regeneration should be accelerating functional recovery and/or reducing the need for autograft; efforts should not simply address metrics of nerve regrowth or conduits to cross nerve gaps. Similarly, efforts to regenerate skeletal muscle should extend beyond restoration of muscle bulk or structure and address restoration of maximal muscle function. 

The Areas of Encouragement include: • Immediate reconnection of severed peripheral nerves (e.g., preventing Wallerian degeneration) • Regeneration of composite muscle and nerve injuries leading to improved function • Regenerative therapies for volumetric muscle loss • Preservation of denervated end organs • Maintenance of the motor end plate or regeneration of the neuromuscular junction • Improving the rate of peripheral nerve regeneration

Eligibility Requirements

Independent investigators at all academic levels (or equivalent) may be named by the organization as the PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.



Amount Description

The anticipated total costs budgeted for the entire period of performance for an FY19 JPC-8/ CRMRP RMFRA award will not exceed $10 million (M). Costs should reasonably reflect the number of projects included in the application and the type and breadth of research proposed and be fully justified. Applications, as well as individual research projects (Multiple PI submissions), may range in size, scope, and duration (up to a maximum of 5 years), as appropriate for the work proposed, and will be equally considered. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. 

Funding Type



Junior Faculty


Engineering and Physical Sciences
Medical - Clinical Science
Medical - Translational

External Deadline

August 7, 2019