The MBRP CTRA is intended to support the rapid implementation of clinical research (including clinical trials) with the potential to significantly impact burn care by applying promising and well-founded research findings to the care of the burn-injured patient, particularly at the point of injury, or during the early, acute phase of burn injury (Roles 1-3 of the military pathway of care).
Impact: The overall impact of the proposed research is a key component of this award mechanism. The potential impact of the research, both short term and long term, in addressing one or more of the FY23 MBRP Focus Areas should be clearly described. Investigators are encouraged to consider the following characteristics as examples of how a project may demonstrate highly impactful research: • Description of how the proposed research addresses a military need within Roles 1-3 of the military pathway of care4 • Explanation of how the project significantly advances the burn research field and the care of burn-injured service members in an austere or resource limited environment • Description of how the proposed research will support the ability to provide care to burn injured patients at, or close to the point of injury, particularly by a combat medic (or equivalent), or a non-medical first responder
Relevance to Military Health: The proposed research must be relevant to Service Members, Veterans, military beneficiaries, and/or the American public. Investigators are encouraged to consider the following characteristics as examples of how a project may demonstrate relevance to military health: • Explanation of how the project addresses an aspect of burn injuries typically associated with combat • Description of how the results of the proposed research will address a military need
Collaborations between researchers at military or Veteran institutions and non-military institutions are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique data and research resources that the partners bring to the research effort, ultimately advancing burn research, which is of significance to the Service Member, military families, and the American public
Deadlines:
• Pre-Application Deadline: May 31, 2023
• Invitation to Submit an Application: July 2023
• Application Submission Deadline: Sep. 4, 2023
In order to meet the MBRP mission to “identify and close gaps in combat burn trauma care through military-focused research,” the program seeks to fund research that enhances the ability to prevent, assess, and/or treat burns/burn-associated complications, which ultimately facilitates the improvement of health and performance outcomes of burn-injured Service Members, Veterans, military beneficiaries, and/or the American public. In addition, the Program is especially interested in research projects focusing on products that can be used by pre-hospital care providers such as combat medics, non-medical first responders such as combat lifesavers, or self/buddy-aid. Within this context, the MBRP is interested in research proposals that address specific gaps in the area of military-relevant burns; therefore, the proposed research must address at least one of the following FY23 MBRP Focus Areas:
• Atypical Burns: Development and/or validation of methods to prevent, triage, and/or treat burns resulting from exposure to cold, radiation, directed energy weapons, or high voltage/combat-related electrical injuries. Novel interventions that go beyond topical agents or dressings are of particular interest.
• Burn Injury During Mass Casualty Incidents: Solutions to improve the triage, delivery, or capacity of care in the immediate aftermath of mass casualty incidents involving burn injuries (incendiary device explosions, multi-passenger vehicle fires, etc.).
• Burn Injury-Related Complications: Development and/or validation of methods to prevent, assess, and/or treat burn injury-related complications, including: ○ Over/under fluid resuscitation to include limited- or low-volume resuscitation ○ Acute Respiratory Distress Syndrome (ARDS) ○ Sepsis ○ Inhalation injuries
Principal Investigators (PIs) at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI on the application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by or affiliated with an eligible organization.
The anticipated total costs budgeted for the entire period of performance for an FY23 MBRP CTRA should not exceed $2M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.
