Congressionally Directed Medical Research Programs -- Multiple Sclerosis Research Program -- Exploration-Hypothesis Development Award

Funding Agency:
Department of Defense

The Exploration – Hypothesis Development Award supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the MS research field. The studies supported by this award mechanism are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a wellformulated, testable hypothesis based on strong scientific rationale and study design. The presentation of preliminary and/or published data is not required.

The proposed research project should be innovative. Innovative research may examine a novel paradigm, challenge current paradigms, look at existing problems from novel perspectives, or exhibit other highly creative qualities. Research that is an incremental advance beyond ongoing research and published data is not considered innovative and is not consistent with the intent of this award mechanism. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly articulate how the proposed research project is innovative in the field of MS research. 


• Required Pre-Application Deadline:  May 21, 2019
• Invitation to Submit an Application: July 2019
• Application Submission Deadline:  September 19, 2019

Agency Website

Areas of Interest

All applications submitted to the FY19 MSRP Program Announcement must address at least one of the following Focus Areas:

1. Promoting Central Nervous System Regenerative Potential in Demyelinating Conditions

2. Correlates of Disease Activity and Progression in MS

3. Biology and Measurement of MS Symptoms

Eligibility Requirements

PIs must be independent investigators at or above the level of Assistant Professor (or equivalent).



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY19 MSRP Exploration – Hypothesis Development Award will not exceed $150,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information

Funding Type



Junior Faculty


Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

May 21, 2019