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Congressionally Directed Medical Research Programs -- Peer Reviewed Alzheimer’s Disease Research Program (MRPRA) -- Epidemiology of Military Risk Factors Research Award
The PRARP Epidemiology of Military Risk Factors Research Award (EMRFA) mechanism is being offered for the first time in FY16.
The intent of the FY16 PRARP EMRFA is to investigate the etiology and epidemiology of military-related TBI and AD/ADRD. The research impact will benefit the military, Veteran, and civilian communities. To this end, the PRARP has identified FY16 EMRFA Overarching Challenges and Focus Areas by which the intent of this mechanism can be facilitated (see Section I.B., FY16 PRARP EMRFA Overarching Challenges and Focus Areas). These should be carefully considered as part of the application process. Applications should describe how the association of TBI and subsequent AD/ADRD will be characterized.
Applications should carefully consider how their studies will characterize the cognitive and behavioral symptoms that result in functional impairments in the proposed identified cohort. Studies that use combinations of measures (e.g., neuropsychological assessments, imaging, genomics, and cerebral spinal fluid biomarkers) are encouraged. Applications that develop interdisciplinary teams or consortia as part of the support plan for executing the research are encouraged.
- REQUIRED Pre-application Submission Deadline: August 17, 2016
- Invitation to Submit an Application: October 5, 2016
- Full Application Submission Deadline: November 9, 2016
Areas of Interest
FY16 PRARP EMRFA Overarching Challenges: This FY16 PRARP EMRFA funding opportunity requires applications to address one or more of the following FY16 PRARP EMRFA Overarching Challenges:
• Paucity of Research Resources: The paucity of research resources to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities.
• Paucity of Clinical Studies: The paucity of clinical studies to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities.
• Diagnostic Technologies, Tests, Biomarkers, or Devices: The need for technologies, tests, or devices to detect the progression to AD/ADRD subsequent to TBI.
• Epidemiology: The paucity of epidemiological research to examine the interrelationship between TBI and subsequent AD/ADRD for the military, Veteran, and civilian communities.
FY16 PRARP EMRFA Focus Areas: In addition to addressing one or more of the specified FY16 PRARP EMRFA Overarching Challenges, applications should address at least one of the following FY16 PRARP EMRFA Focus Areas in support of the FY16 PRARP EMRFA Overarching Challenges. An application that proposes research outside of these FY16 PRARP EMRFA Focus Areas is acceptable, as long as the applicant provides a strong rationale.
• Genomics/Proteomics: Studies or technologies (e.g., genetic, proteomic, and epigenetic strategies) intended to characterize neurological change(s) associated with TBI and subsequent AD/ADRD. In addition, relevant technologies or tests may be considered under this focus area.
• Diagnostics and Biomarkers: Development of strategies to characterize neurological changes associated with TBI and subsequent AD/ADRD (e.g., fluid-based, imaging, physiological, and clinical approaches).
• Epidemiological Research: Research focusing on the incidence, distribution, outcomes, and other factors relating to the health of individuals affected by TBI and subsequent AD/ADRD.
The PI must be an independent investigator at or above the level of Assistant Professor (or equivalent).
• The maximum period of performance is 4 years. • The anticipated total costs (direct and indirect) budgeted for the entire period of performance will not exceed $2.5M. Indirect costs are to be budgeted in accordance with the organization’s negotiated rate. No budget will be approved by the Government exceeding $2.5M total costs or using an indirect rate exceeding the organization’s negotiated rate. • The applicant may request the entire maximum funding amount for a project that may have a period of performance less than the maximum 4 years. • All direct and indirect costs of any subaward (subgrant or subcontract) must be included in the total direct costs of the primary award.