Congressionally Directed Medical Research Programs -- Peer Reviewed Alzheimer’s Disease Research Program -- New Investigator Research Award

Funding Agency:
Department of Defense

The intent of the FY18 PRARP NIRA is to support early-career investigators interested in novel research efforts or new technologies within TBI and AD/ADRD in support of the PRARP’s mission (see Section II.A, Program Description). The research impact for the FY18 PRARP NIRA is expected to benefit the military, Veteran, and civilian communities.

The FY18 PRARP NIRA is open to eligible applicants whose named Principal Investigators (PIs) are within 3 years of their first independent faculty position, from any field or discipline. The application should demonstrate the study team’s experience in both TBI and AD/ADRD research. Preliminary data, while not required, are encouraged. Preliminary data may come from the PI’s published work, pilot data, or from peer-reviewed literature. Note that applicants will be required to verify PI eligibility for this award.


  • REQUIRED Pre-application Submission Deadline:  September 20, 2018
  • Full Application Submission Deadline:  October 4, 2018

Agency Website

Areas of Interest

  • Mechanisms of Pathogenesis: Identification of contributing mechanisms (e.g., diffuse/ traumatic axonal injury, roles of non-neuronal cells, neuroinflammation, immune regulation, biology/pathology of tau, vascular contributions, and omics techniques for examining mechanisms) associated with TBI and subsequent AD/ADRD pathogenesis.
  • Biomarkers: Development of strategies to diagnose, prognose, or characterize neurological changes or risk factors associated with TBI and subsequent AD/ADRD (e.g., fluid-based, imaging-based, physiological, and omics techniques for biomarkers).
  • Quality of Life: Research intended to alleviate, stabilize, or characterize the symptoms, or deficits, common to TBI, AD, and ADRD. Examples of research in this Focus Area include identification and management of comorbidities and modifiable risk factors (e.g., sleep apnea, obesity), cognitive training interventions, studies of health and wellness and behavioral interventions.
  • Caregiver Support: Research intended to enhance the role of the caregiver for individuals living with the common symptoms or deficits of TBI and AD/ADRD. Examples of research in this Focus Area include caregiver training, home-based support, behavioral interventions, and relationship interventions.
  • Epidemiological Research: Research focusing on the incidence, distribution, and other factors relating to the health of individuals affected by TBI and subsequent AD/ADRD.
  • Novel Target Identification: Basic research (non-human) directly leading to the identification of new targets for the development of existing or new investigational medicines, drugs, or agents.
  • Nonpharmacological Interventions: Research into non-medication-based interventions to improve quality of life or caregiving for those living with AD/ADRD. 

Eligibility Requirements

TThe PI must be an independent, early-career investigator within 3 years of his/her first independent faculty position (or equivalent) at the time of the application submission deadline.



Amount Description

The anticipated direct costs budgeted for the entire period of performance for an FY18 PRARP NIRA will not exceed $225,000. The maximum period of performance is 3 years. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

September 20, 2018