Congressionally Directed Medical Research Programs -- Peer Reviewed Alzheimer’s Research Program -- Transforming Research Award

Funding Agency:
Department of Defense

The PRARP TRA mechanism is being offered for the first time in FY23.

The FY23 PRARP TRA is intended to support studies that will make transformative and advanced contributions to reduce risk of or prevent the development of AD/ADRD. Risk reduction considering TBI and/or military service is of particular interest to the program. The work should significantly accelerate efforts in AD/ADRD research and demonstrate significant positive impact toward improving patient care and/or quality of life.

Optimizing Research Impact Through Community Collaboration: Research funded by the FY23 PRARP should be responsive to the needs of people living with AD/ADRD. Establishment and utilization of effective and equitable collaborations and partnerships with members of the AD/ADRD lived experience, family, and care partner communities, maximizes the translational and impact potential of the proposed research. For the FY23 PRARP TRA, inclusion of collaborative community partner approaches is required for all projects involving clinical research.


• Pre-Application Submission Deadline: May 31, 2023

• Application Submission Deadline:  July 10, 2023

Agency Website

Areas of Interest

To meet the intent of the award mechanism, applications submitted to this program announcement must address the FY23 PRARP TRA Prevention and Risk Reduction Focus Area. The proposed research may include, but is not limited to, exploring questions in the following areas:

• Identification of risk factors, including but not limited to environmental, genetic, epigenetic, and lifestyle.

• Identification and implementation of culturally competent strategies to reduce AD/ADRD risk and prevent cognitive problems following TBI and/or military service.

• Understanding the role of social determinants of health in risk reduction.

• Informational (not descriptive) epidemiology to understand environmental and other factors that contribute to development of AD/ADRD.

These areas are defined broadly, and the examples cited above are not intended to preclude or constrain other types of projects related to the TRA Focus Area. All projects submitted to this Focus Area must clearly demonstrate how the research will be culturally competent and inclusive.

Eligibility Requirements

The PI named by the organization on the application must be an independent investigator at any career level.

Career Initiation or Transition Partnering PI Option: To be eligible for this option, at least one of the PIs named on the award must meet the following criteria: 1) Career initiation investigators must have at least 3 years research experience beyond a terminal degree but no more than 7 years within their first independent research position. OR 2) Career transition investigators may be any level, but new to either the TBI and/or AD/ADRD fields, with nominal, if any, publications and/or support. Lapses in research time or appointments as denoted in the biographical sketch should be explained in the application. The other PI may be an independent investigator at any academic level (or equivalent).



Amount Description

The anticipated total (direct plus indirect) costs budgeted for the entire period of performance for an FY23 PRARP TRA should not exceed $1M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

Funding Type



Junior Faculty
Post Doctoral Fellows


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

May 31, 2023