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Congressionally Directed Medical Research Programs -- Psychological Health/Traumatic Brain Injury Research Program -- Complex Traumatic Brain Injury Rehabilitation Research Clinical Research Award
The FY17/18 PH/TBIRP Complex TBI Rehabilitation Research – Clinical Research Award (CTRR–CRA) is intended to support clinical research focused on understanding the clinical sequelae and mechanisms of recovery associated with TBI and TBI rehabilitation interventions. The overarching goals of this award are to address TBI-related impairments and deficits including sensory, sensorimotor, and cognitive dysfunction to (1) develop and validate rehabilitation outcome measures; (2) define and evaluate mechanisms of injury progression or recovery associated with rehabilitation interventions; and (3) improve clinician-driven assessment strategies to guide return-to-duty decision making.
The FY17/18 PH/TBIRP CTRR–CRA Program Announcement supports applied and translational research to advance the development of knowledge and materiel products for rehabilitation and restoration of function following TBI. PIs should explain how their work will inform the development, refinement, and/or revision of existing standards of care, clinical recommendations, or guidelines.
• Pre-Application Deadline: October 11, 2017
• Invitation to Submit an Application: November 10, 2017
• Application Submission Deadline: December 27, 2017
Areas of Interest
The FY17/18 PH/TBIRP CTRR–CRA seeks research on the affected patient populations, mechanisms of comorbidities, and potential interventions relevant to TBI rehabilitation and the mission of the JPC-8/CRMRP. To meet the intent of the award mechanism, applications must be responsive to one or both of the following two FY17/18 PH/TBIRP CTRR–CRA Focus Areas:
1. Mechanisms: Investigate mechanisms of recovery following isolated or cumulative TBI(s) in Service member-relevant injuries. Investigators should explore at least one of the following:
• Cognitive Deficits – To inform novel rehabilitation interventions that lead to the recovery of cognitive function.
• Sensory or Sensorimotor Dysfunction – To inform novel rehabilitation interventions that lead to recovery of sensory or sensorimotor function.
2. Ecological Assessment: Develop, evaluate, and/or validate return-to-duty outcome measures following rehabilitation in patients with TBI. Outcome measures may integrate novel or commercially available assessment technologies to enhance measure sensitivity and/or specificity. Priority will be given to outcome measures that are both ecologically valid (i.e., focused on military-specific tasks) and clinically feasible with an aim to inform return-to-duty/participation decisions in either an operational or garrison-based environment. In addition, strong applications will articulate the potential for future impact on return-towork outcomes in both military and civilian environments. All outcome measures should quantify and characterize patient impairments, functional limitations, and barriers to participation, and the research Project Narrative should have a strong plan for validation in Service member, to include cadet, populations.
Independent investigators at all academic levels (or equivalent) are eligible to submit an application
The anticipated total costs budgeted for the entire period of performance for an FY17/18 PH/TBIRP CTRR–CRA will not exceed $2.0 Million (M). Refer to Section II.D.5, Funding Restrictions, for detailed funding information.