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Congressionally Directed Medical Research Programs -- Reconstructive Transplant Research Program -- Concept Award
The RTRP Concept Award mechanism was first offered in FY15. Since then, 129 Concept Award applications have been received, and 18 have been recommended for funding.
The intent of the FY18 RTRP Concept Award is to support the exploration of a highly innovative new concept or untested theory that addresses an important problem relevant to reconstructive transplantation and the FY18 RTRP Focus Areas. The Concept Award is not intended to support a logical progression of an already established research project, but instead supports high-risk studies that have the potential to reveal entirely new avenues for investigation.
• Pre-Application Deadline: October 3, 2018
• Application Submission Deadline: October 24, 2018
Areas of Interest
To meet the intent of the FY18 RTRP Concept Award mechanism, applicants must address at least one of the FY18 RTRP Focus Areas listed below.
• Reduce the risks of VCA-associated immunotherapy ○ Define the mechanisms of VCA immunogenicity ○ Determine the extent to which VCA tissue preservation technology impacts VCA immune response ○ Develop novel approaches for immune tolerance ○ Reduce the toxicity of standard immunosuppression ○ Identify key similarities and differences between immunosuppression associated with VCA and solid organ transplant ○ Identify and/or validate new peripheral biomarkers for early acute and chronic rejection
• Revolutionize ex vivo VCA tissue preservation strategies to extend the timeline between procurement and transplantation
• Identify near- and long-term functional, quality-of-life, and psychosocial outcomes in VCA, and their influencing factors ○ Identify criteria for optimizing successful patient selection and outcomes ○ Develop quality-of-life measures ○ Identify factors that influence psychological adjustment and a return to full participation in community life ○ Standardize transparent outcomes data for VCA recipients (multi-institutional) ○ Identify factors influencing donor registration and authorization ○ Identify factors impacting a patient’s decision to pursue VCA
Investigators at or above the level of postdoctoral fellow (or equivalent) are eligible to be named as the PI on an application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.
The anticipated total costs budgeted for the entire period of performance for an FY18 RTRP Concept Award will not exceed $200,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.