The intent of the FY22 RTRP Concept Award is to support the exploration of a highly innovative new concept or untested theory that addresses an important problem relevant to reconstructive transplantation and the FY22 RTRP Concept Award Focus Areas. The Concept Award is not intended to support a logical progression of an already established research project, but instead supports high-risk studies that have the potential to reveal entirely new avenues for investigation.
Deadlines:
• Required Pre-Application Deadline: Sep. 28, 2022
• Application Submission Deadline: October 19, 2022
To meet the intent of the FY22 RTRP Concept Award (CA) mechanism, applicants must address at least one of the FY22 RTRP Concept Award Focus Areas listed below (Select both a bolded Focus Area and the appropriate subtopic):
Reduce the risks of VCA-associated immunosuppression
- Define the unique manifestations and/or mechanisms of VCA immunogenicity
- Develop novel approaches for achieving VCA immune tolerance
- Develop less-toxic and/or personalized regimens for maintenance immunosuppression
- Identify unique immunosuppression requirements for VCA compared to other solid organ transplants
Identify reliable non-invasive prognostic/diagnostic biomarkers, methods, or tools for monitoring VCA graft rejection, including applications that would be suitable for point-ofcare testing or home monitoring
- Identify new peripheral biomarkers for acute and chronic VCA graft rejection in human subjects or banked human specimens and medical records suitable for use in the clinic or at home
- Develop assays or devices for clinical implementation of graft monitoring utilizing validated biomarkers
Investigators at or above the level of postdoctoral fellow (or equivalent) are eligible to be named as the PI on an application. An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.
The anticipated total costs budgeted for the entire period of performance for an FY22 RTRP Concept Award will not exceed $200,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.