The intent of the FY21 TBIPHRP IDA is to support innovative, non-incremental, high-risk/ high-reward research that will provide new insights, paradigms, technologies, or clinical applications. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a wellformulated, testable hypothesis based on a sound scientific rationale and study design. Preliminary data is not required.

Research deemed innovative may represent a new paradigm, challenge current paradigms, look at existing problems from new perspectives, leverage unique study populations, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative. Projects involving multidisciplinary and/or data science approaches are especially encouraged.

Due to this award’s emphasis on innovation, inclusion of preliminary data is allowed but not required. The presentation of substantial preliminary data suggests that the proposed research project would be more appropriately submitted to a different award mechanism. Absence of preliminary data will not negatively affect scientific or programmatic review of the application. Any unpublished, preliminary data provided should originate from the laboratory of the Principal Investigator (PI) or members of the research team. Regardless of whether preliminary data are included, applications should be based on a sound scientific rationale that is established through logical reasoning and/or critical review and analysis of the literature. The outcome of research supported by this award should include the generation of robust preliminary data that can be used as a foundation for future research projects.

Deadlines:

• Required Pre-Application Deadline: September 8, 2021
• Application Submission Deadline: September 30, 2021