Consortium on Translational Research in Early Detection of Liver Cancer: Translational Research Centers (U01)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) is a part of an initiative designed to establish a Liver Cancer Consortium to advance translational research focused on early detection of liver cancer.  The Consortium will consist of several Translational Research Centers (TRCs, to be supported by this U01 FOA) and a Data Management and Coordinating Center (DMCC, to be supported a companion U24 FOA, RFA-CA-17-028).

The TRCs will conduct studies to improve the surveillance of liver cancer in members of high-risk populations, increase the fraction of liver cancer detected at an early stage, and better stratify patients at risk of developing liver cancer. Research to be conducted by TRCs must be based on appropriate range of biospecimens from cohorts that are focused on cirrhotic patients. A major collaborative effort of the TRCs will be the establishment of a well annotated repository of biospecimens. Biospecimens (blood, other body fluids, and, when feasible, liver tissue) may be already available and/or may be prospectively collected.

To achieve these goals, each proposed TRC should include laboratory and clinical researchers with multi-disciplinary expertise in such areas as early cancer detection, biomarkers, cancer surveillance, imaging, and biospecimen science.

The TRCs will be expected to interact closely with the DMCC and engage in collaborative activities with other members of the Liver Cancer Consortium.

The TRCs individual research projects as well as trans-network collaborative activities of the Consortium will be supported scientifically and coordinated administratively and logistically by the DMCC.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): October 24, 2017​

RFA-CA-17-025 Expiration Date October 25, 2017

Agency Website



Amount Description

An Applicant may request a budget of up to $550,000 per year (direct costs).

 A project period of up to 5 years may be requested.  

Funding Type





Medical - Clinical Science
Medical - Translational

External Deadline

October 24, 2017