Consortium on Translational Research in Early Detection of Liver Cancer: Translational Research Centers (U01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) is soliciting applications for a Liver Cancer Consortium focused on advancing translational research in the early detection of liver cancer. Translational Research Centers (TRCs) will conduct studies to improve the surveillance of liver cancer in members of high-risk populations, increase the fraction of liver cancer detected at an early stage, and better stratify patients at risk of developing liver cancer. A major collaborative effort of the TRCs will be establishing an integrated blood and image repository with annotated clinical data from patients found to have indeterminate nodules during liver cancer surveillance. To achieve these goals, each proposed TRC should include laboratory and clinical researchers with multi-disciplinary expertise in such areas as early cancer detection, biomarkers, cancer surveillance, imaging, and biospecimen science.

The Consortium will consist of several Translational Research Centers (TRCs, to be supported by this U01 FOA) and a Data Management and Coordinating Center (DMCC, to be supported through a companion U24 FOA, RFA-CA-22-032). The TRCs will be expected to interact closely with the DMCC and engage in collaborative activities with other members of the Liver Cancer Consortium.


  • Letter of Intent Due Date(s): 30 days prior to the application due date

  • Application Due Date: November 07, 2022

RFA-CA-22-031 Expiration Date November 08, 2022

Agency Website



Amount Description

An Applicant may request a budget of up to $550,000 per year (direct costs).

The maximum project period is five years.

Funding Type





Medical - Clinical Science
Medical - Translational

External Deadline

November 7, 2022