Countermeasures Against Chemical Threats (CounterACT) Exploratory/Developmental Projects (R21 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) encourages applications for NIH Countermeasures Against Chemical Threats (CounterACT) exploratory/developmental (R21) projects. The mission of the NIH CounterACT program is to foster and support research that will advance development of new and improved therapeutics to mitigate the health effects of chemical threats. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pesticides, and pharmaceutical-based agents. Projects supported by this FOA are expected to generate preliminary data that would facilitate the development of competitive applications for more extensive support from theNIH CounterACT Cooperative Agreement programsor other related initiatives.

Companion FOAs:


PAR-19-039 -U01Research Project – Cooperative Agreements

PAR-19-040 -U01Research Project – Cooperative Agreements
PAR-18-657 -U54 Specialized Centers - Cooperative Agreements


  • Letter of Intent Due Date: 30 days before the application due date
  • Application Due Date(s): May 26, 2021; May 31, 2022; May 30, 2023

PAR-20-253 Expiration Date May 31, 2023

Agency Website



Amount Description

The budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

Funding Type





Engineering and Physical Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

May 31, 2022