Countermeasures Against Chemical Threats (CounterACT) Exploratory/Developmental Projects in Translational Research (R21 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) exploratory/developmental translational research (R21). The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics to mitigate the health effects of chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pesticides, and pharmaceutical-based agents. The scope of the research includes basic toxicological research on the chemical threat for the purpose of target and therapeutic hit identification, hit validation, lead optimization, and demonstration of in vivo ADME/Tox and efficacy. Projects supported by this FOA are expected to generate preliminary data that would facilitate the development of competitive applications for more extensive support from the NIH CounterACT Cooperative Agreement programs or other related initiatives. 

Companion FOAs:

PAR-16-331U01 Research Project Cooperative Agreements
PAR-16-330U01 Research Project Cooperative Agreements
PAR-18-657, U54 Specialized Centers - Cooperative Agreements


  • Letter of Intent Due Date: 30 days before the application due date
  • Application Due Date(s): May 30, 2018; May 28, 2019; May 26, 2020

PAR-18-721 Expiration Date May 27, 2020

Agency Website



Amount Description

The budget for direct costs for the two year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.

Funding Type





Engineering and Physical Sciences
Medical - Translational

External Deadline

May 28, 2019