Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54 Clinical Trial Optional)

Funding Agency:
National Institutes of Health
This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54s). The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides.  The scope of the research includes target and candidate identification and characterization, through candidate optimization and demonstration of in vivo efficacy consistent with the product's intended use in humans. For applicants submitting U54 renewal applications, research under this FOA should culminate in an optimized lead compound ready for advanced development. The Centers will contain at least three research projects supported by an administrative core, up to three optional scientific cores, and a research education core.  Each research project must include milestones that create discrete go or no-go decision points in a progressive translational study plan. 
Companion FOAs:
PAR-16-330, U01 Research Project – Cooperative Agreements
PAR-16-331, U01 Research Project – Cooperative Agreements



  • Letters of Intent Receipt Date(s): 30 days before the application due date
  • Applications: September 11, 2018; September 10, 2019; October 8, 2020

PAR-18-657 Expiration Date: New Date October 9, 2020 per issuance of NOT-NS-20-086. (Original Expiration Date: September 10, 2020)

Agency Website



Amount Description

Application budgets may not exceed $2.5 million in direct costs per year.

Many applications will not need to request the maximum budget and the size and duration of the awards will vary because the nature and scope of research programs will vary.

 The total project period may not exceed 5 years.  

    Funding Type





    Engineering and Physical Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    External Deadline

    October 8, 2020