DARPA Biological Technologies Office BAA -- HR001120S0044

Funding Agency:
Defense Advanced Research Projects Agency

The mission of BTO is to foster, demonstrate, and transition breakthrough fundamental research, discoveries, and applications that integrate biology, engineering, computer science, mathematics, and the physical sciences. BTO’s investment portfolio goes far beyond life sciences applications in medicine to include areas of research such as human-machine interfaces, microbes as production platforms, and deep exploration of the impact of evolving ecologies and environments on U.S. readiness and capabilities. BTO’s programs operate across a wide range of scales, from individual cells to the warfighter to global ecosystems. BTO responds to the urgent and long-term needs of the Department of Defense (DoD) and addresses national security priorities. 

Proposal Abstracts and Full Proposals will be accepted on a rolling basis until April 22, 2021.

Agency Website

Areas of Interest

BTO is interested in submissions related to the following areas:

  • Discovering and leveraging novel findings from biotechnology, biochemistry, molecular biology, neuroscience, psychology, cognitive science, and related disciplines to advance treatment and resilience in neurological health, transformative neural processing, and optimize human performance.
  • Understanding and improving interfaces between the biological and physical world to enable seamless hybrid systems and revolutionary new human-machine interfaces.
  • Designing novel materials, sensors, or processes that mimic or are inspired by biological systems.
  • Leveraging and translating a biological system’s underlying design rules, functional processes, and/or means of interactivity to provide insight into or control over complex biological systems from biofilms to organs.
  • Developing new tools and capabilities for forward engineering of biological systems, such as cells, tissues, organs, organisms, and complex communities, to both develop new products and functional systems, as well as to gain new insights into underlying mechanisms.
  • Developing new platform technologies that integrate, automate, and miniaturize the collection, processing, and analysis of biological and chemical samples.
  • Developing technologies that leverage ecological diversity and/or help support human operations in extreme environments (ocean, desert, space, arctic, etc.).
  • Developing and validating new theories and computational models that identify factors and principles underlying collective and interactive behaviors of biological organisms at all scales from individual cells to global ecosystems.
  • Understanding the dynamics of population and ecosystem behavior to preserve equilibrium, provide strategic opportunity, or avoid catastrophe.
  • Developing and leveraging new technologies that can be applied to agricultural ecosystems for production stabilization, by improving quality or reducing losses from pathogens or pests.
  • Developing and leveraging new insights into non-human biology across and between populations of microbes, insects, plants, marine life, and other non-human biologic entities.
  • Developing technologies to leverage biological systems and enhance the ability to acquire and maintain critical and strategic organic and inorganic materials.
  • Developing new technologies and approaches that ensure biosafety, biosecurity, digital biosecurity of biological hardware, data and information, and protection of the bioeconomy.
  • Understanding emerging threats to global food and water supplies and developing countermeasures that could be implemented on regional or global scales.
  • Developing new technologies to treat, prevent, and predict the emergence and spread of infectious diseases that have the potential to cause significant health, economic, and social burden.
  • Developing and leveraging technologies to advance continuous or near-continuous monitoring of an organism’s physiology to elucidate mechanisms of human resilience.
  • Developing new technologies for the rapid manufacturing, delivery and distribution of large molecule drugs such as biologics.
  • Leveraging biology to provide new tactical and strategic maritime operational advantages 
  • Developing an understanding of mechanisms that organisms use to assess and interact with their environment.
  • Developing new technologies for advanced eukaryotic cellular engineering to support next generation cellular therapeutic applications.
  • Developing new platform technologies for targeted, effective, spatiotemporallycontrolled delivery of large and small molecules and biologics.
  • Developing tools to understand the underlying rules defining biomolecular and biomaterial structure/function properties in order to predict desired outcomes for novel materials.
  • Leveraging biological systems to produce solutions for antimicrobial resistance.
  • Other biological technology topic areas that fit the national security scope of BTO’s mission

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences

External Deadline

April 22, 2021