The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall, the IMPC hopes to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. However, a large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research.
Deadlines:
- Letters of Intent Due Date(s): 30 days before application due date(s)
- Application Due Dates(s): June 5, 2025; Oct. 5, 2025
PAR-25-140 Expiration Date January 08, 2026
Budgets with direct costs of up to $499,999 per year may be requested.
The scope of the proposed project should determine the project period. The maximum project period is 5 years.