is compiled and published solely as an informational service to Duke
researchers, scholars, and staff.
National Institutes of Health - Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R01, R21)
This funding opportunity announcement (FOA), is intended to encourage grant applications that propose further investigation of known examples of transgenerational inheritance in mammals (i.e., through the F3 generation after prenatal exposure) occurring after exposure to environmental toxicants. Exploratory (R21) studies will be supported under a companion FOA, RFA-ES-12-007.
This FOA is intended to support more developed research programs, where preliminary data (published or unpublished) has demonstrated transgenerational inheritance in mouse or rat models through at least the F3 generation (or the F2 generation following adult exposures).
Applications suitable for this FOA include, but are not limited to, the following:
- Investigate the mechanism(s) by which environmentally-induced phenotypes are transmitted from generation to generation
- Characterize strain-specific transgenerational responses and/or identify genetic factors that contribute to susceptibility to transgenerational inheritance
- Investigate the basis of sex differences in transmission of transgenerational phenotypes
- Define specific developmental windows of susceptibility prone to inducing transgenerationally-inherited phenotypes (prenatal or postnatal)
- Examine the interaction between an environmental exposure and another stressor (e.g., stress, nutrition, drugs) in stimulating transgenerational responses.
- Characterize the suite of endpoints/diseases/dysfunctions in the F3 generation as a result of exposure to the F1 generation and compare to the suite of endpoints affected in the F1 generation.
- Letter of Intent Due Date: November 19, 2012
- Application Due Date(s): December 18, 2012, by 5:00 PM local time of applicant organization.
RFA-ES-12-006 Expiration Date December 19, 2012
The official announcement and description of this opportunity may
be found on the funding agency's website:
Environmental & Life Sciences; Medical - Basic Science; Medical - Clinical Science.
Direct costs are limited to $500,000 per year. Scope of the proposed project should determine the project period. The maximum period is 5 years.
External Deadline: 12/18/2012
|Note: For Duke researchers, scholars, and staff.
Duke University is served by two pre-award offices. The
Office of Research Support assists Campus Schools and Centers. The
Office of Research Administration supports the School of Medicine and
the School of Nursing in Duke University Medical Center.
|The Office of Research Administration -
For School of Medicine and School of Nursing
|The Office of Research Support -
For Campus Schools and Centers
|The Office of Research Administration must review all Duke University Medical Center applications for the School of Medicine and School of Nursing prior to submission to the sponsor. Business proposals are due at the ORA offices seven (7) business days in advance of the sponsor deadline.
||The Office of Research Support must review all Duke University applications for Campus Schools and Centers prior to submission to the sponsor. Business proposals are due at the ORS offices five (5) business days in advance of sponsor the deadline.
|The Office of Research Administration
Duke University Medical Center
Suite 802, Erwin Square
2200 West Main Street
Durham, NC 27705
|The Office of Research Support
Suite 710 Erwin Square
2200 West. Main Street
Durham, NC 27705
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Last updated 8/23/2012