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Development and Characterization of Animal Models for Aging Research (R01, R21)
The purpose of this announcement is to promote research that develops, characterizes, refines, and enhances model systems for research on aging.
This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with another FOA of identical scientific scope, PA-13-156, that solicits applications under the Exploratory/Developmental Research Grant (R21) mechanism.
- R01 Deadlines: Feb. 5, Jun. 5, Oct. 5.
- R21 Deadlines: Feb. 16, Jun. 16, Oct. 16.
- AIDS Deadlines: Jan. 7, May 7, Sep. 7.
PA-13-155 Expiration Date: September 8, 2016
Areas of Interest
Types of research and experimental approaches that are being sought to achieve these objectives include, but are not limited to:
- the use of high-throughput technologies such as metabolomics and proteomics to characterize age-associated physiological changes in rodent models
- characterization of health span, lifespan, and physiological aging in animal models not currently used for aging research, such as mouse models of obesity, diabetes, and oxidative stress
- analyses of changes in physiology and pathology across the rodent lifespan, with the goal of determining the age when such changes appear
- development of unique cell lines of value to aging research such as induced pluripotent stem (iPS) cells from rodent models of normal aging and age-related diseases, such as, but not limited to, dwarf mice and models of accelerated senescence
- comparative biology studies in mammalian species, particularly rodents and non-human primates, to identify common mechanisms in normal aging and aging-related conditions
- characterization of alternative models for normal aging and aging-related diseases, including unique vertebrate species such as fish and birds
- investigation of the impact of genetic background on aging-related phenotypes
- investigation of the effects of environment on aging phenotypes, such as high-fat diets, environmental enrichment, or known microbiome
- development of informatics tools to integrate diverse type of data on aging in animal models