Sponsor Deadline
Posted: 3/18/2024

Development of Innovative Informatics Methods and Algorithms for Cancer Research and Management (R21 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity (NOFO) is to invite exploratory/developmental research grant applications (R21) for innovative informatics methods and algorithms to improve the acquisition, analysis, visualization, or interpretation of data across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, the emphasis of this NOFO is on supporting the development of novel informatics capabilities that involve a high degree of innovation that have the potential to accelerate or enhance research. To be successful, there must be a clear rationale for how the proposed informatics method or algorithm is novel and how it will benefit the cancer research field. Projects with a significant level of data generation and/or data analysis will not be considered responsive to this funding opportunity.

ITCR provides support for informatics technology development through four NOFOs aimed at distinct phases of the technology development lifecycle:

  • RFA-CA-24-016 (this NOFO, R21, Clinical Trial Optional) Supports the development of highly innovative informatics methods and algorithms
  • RFA-CA-24-017 (U01, Clinical Trial Optional) Supports initial tool development or the significant modification of existing tools for new applications
  • RFA-CA-24-018 (U24, Clinical Trial Optional) Supports the continued development of emerging informatics technology that has passed the initial prototyping and pilot development stage, has demonstrated potential to have a significant and broader impact, has compelling reasons for further improvement and enhancement
  • RFA-CA-24-019 (U24, Clinical Trial Optional) Supports sustaining operations and improving the user experience and availability of existing, widely-adopted informatics tools and resources


  • Letter of Intent Due Date: 30 days before the due date
  • Application Due Date(s): June 11, 2024; Nov. 15, 2024

RFA-CA-24-016 Expiration Date November 16, 2024

Amount Description

The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.