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Developmental Mechanisms of Human Structural Birth Defects (P01)
The purpose of this funding opportunity announcement (FOA) is to support innovative, multidisciplinary, interactive, and synergistic program projects that integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of significant congenital human malformations. To contain costs, each program project will consist of only three component research projects, as well as associated cores. At least one project must use basic research in an animal model system and at least one project must be clinical or translational in nature. The component research projects must share a common central theme, focus, or objective on a specific major developmental defect or malformation that is genotypically, mechanistically, biologically, or phenotypically analogous or homologous in both animal models and humans. Any non-mammalian or mammalian animal model may be used, as long as it contributes to the common overall theme or objective of the program project. The component research projects should share a common developmental gene, process, mechanism, pathway, or phenotype.
- Letter of Intent Due Date(s): 30 days prior to the application due date
- Application Due Date(s): December 16, 2016
RFA-HD-17-017 Expiration Date: December 17, 2016
The PD/PI of the overall P01 Program Project should be an established scientist with demonstrated administrative capabilities.
New (Type 1) and Renewal (Type2) applications may request up to $1,000,000 in direct costs (excluding subcontract Facilities and Administrative [F&A] costs) for each project year. Direct costs for each project year may exceed $1,000,000 with appropriate scientific justification provided subtotal direct costs do not exceed $5,000,000 over 5 years.
No annual increases in noncompeting years may be requested.
Applicants should discuss equipment requests with NICHD staff early in the planning phase and must receive permission from the Institute to include equipment costs in their budget request. Final decisions on equipment requests will depend on the nature of the justification and the Institute's fiscal situation.
The scope of the proposed project should determine the project period. The maximum project period is 5 years.