Duke Translational Research Institute -- DTRI Transformative Funding Agreement [For Duke Faculty Only]

Funding Agency:
Duke University

 The DTRI Transformative Funding Agreement provides funding up to $350,000 to address the T1 valley of death: the gulf between novel clinically motivated research and products that show safety and efficacy in humans (Coller BS and Califf RM, 2009). This program seeks to provide funding for development of mature research that if successful will attract significant interest for external partnering. The goal of this program is to enable and accelerate translation of research out of the academic environment (i.e. new company formation, license, or partnership).

The Primary source of funding is from Duke's Clinical and Translational Science Award (CTSA)


  • Letter of Intent (Optional): 2016-2018 Cycle: January 22, 2016 
  • Application Submission Deadline: 2016-2018 Cycle: February 29, 2016

Agency Website

Eligibility Requirements

  • The Principal Investigator (PI) must be at the regular rank Assistant, Associate or Professor level at Duke University.
  • The proposed project should be innovative, high-risk, and high-impact that if successful will attract significant interest for external partnering. Applicants will work toward major milestones that will enable translation out of the academic environment.
  • Applicants are encouraged but not required to bring funding partners, matching discretionary or departmental funds, or commitments from other sources to supplement CTSA support and accelerate research or broaden aims. Applicants must show that they have considered collaboration with other NCATS initiatives including Bridging Interventional Development Gaps (BrIDGs) and Therapeutics for Rare and Neglected Diseases (TRND) to compress timelines and access available expertise.
  • Faculty members may not serve as PI on more than one concurrently funded Duke CTSA pilot award, with the exception of Core Facility Vouchers and NIH Supplemental Award.



Funding Type





Engineering and Physical Sciences
Medical - Clinical Science
Medical - Translational

External Deadline

February 29, 2016