This FOA encourages research projects on the role of aging-related changes in systemic, peripheral, and/or non-neuronal factors – individually or in combination – to the pathogenesis, presentation, and/or progression of Alzheimer’s disease (AD). The goal of this FOA is to support innovative multidisciplinary research that will integrate the AD science with the basic biology of aging and clinical aging research. Successful studies may identify critical processes and pathophysiological pathways to inform novel prevention or intervention strategies for AD and other dementias of aging. Successful applications will likely involve a broad range of expertise including the biology of aging, geriatrics/gerontology, neurodegenerative diseases, and other clinical and translational specialties focused on systemic diseases or specific tissue/organ pathophysiology to identify interrelationships among peripheral systems and the brain.    

R01 Due Dates: Feb. 5, Jun. 5, Oct. 5

PAR-17-029 Expiration Date November 6, 2019