Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this funding opportunity announcement (FOA) is to support preclinical HIV/AIDS research using NHP models performed by Early Stage Investigators (ESIs) who are within 10 years of their terminal degree or completion of their residency training but who have at least two years of postdoctoral experience. The goal of this support is to help advance HIV/AIDS researchers using NHP models in preclinical research by providing a degree of independence for these ESIs to develop new research directions and to position these researchers to be competitive for new research funding (e.g., R01). Proposed projects must use NHPs as preclinical models for HIV/AIDS research. This funding initiative encompasses all priorities of the fiscal year (FY) 2021-2025 NIH Strategic Plan for HIV and HIV-Related Research (https://www.oar.nih.gov/hiv-policy-and-research/strategic-plan): reduce the incidence of HIV; develop next-generation HIV therapies; conduct research toward HIV cure; address HIV-associated comorbidities, coinfections, and complications; and advance cross-cutting areas of research.

Companion FOA: PAR-22-248 , K01 Research Scientist Development Award - Research & Training

AIDS Application Due Date(s): Jan. 7, May 7, Sep 7

PAR-22-252 Expiration Date September 08, 2025

Agency Website

Eligibility Requirements

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from diverse backgrounds, including underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

Applicants for this award must meet the NIH definition of an Early Stage Investigator. Additional requirements for eligibility are that the applicant must have a research or health-professional doctoral degree, must have completed at least two years of postdoctoral training or equivalent, must be within 10 years of their terminal degree or completion of residency, and must be an Assistant Professor, Assistant Scientist, Research Assistant Professor, or equivalent.

Professors, Associate Professors or equivalent are not eligible.

The candidate should have an appointment at an institution that includes an NHP facility, such as a National Primate Research Center or similar, which can provide NHPs, core facilities and intellectual resources for using NHPs in HIV/AIDS research. If exceptionally well justified, the candidate may have a primary appointment at an institution distinct from those which houses NHP-related facilities and infrastructure. However, all work directly related to animals must be performed at the institution that houses the NHP-related facilities and related infrastructure.



Amount Description

No more than $200,000 in direct costs may be requested in any single year. The combined budget may not exceed $400,000 direct costs for the two-year period.

Funding Type



Junior Faculty


Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

January 7, 2023