Ecology and Evolution of Infectious Diseases (EEID)

Funding Agency:
National Science Foundation

The multi-agency Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, organismal, and social drivers that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be the quantitative, mathematical, or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease (re)emergence and transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should focus on the determinants and interactions of (re)emergence and transmission among any host species, including but not limited to humans, non-human animals, and/or plants. This includes, for example, the spread of pathogens; the influence of environmental factors such as climate; the population dynamics and genetics of vectors and reservoir species or hosts; how the physiology or behavior of the pathogen, vector, or host species biology affects transmission dynamics; the feedback between ecological transmission and evolutionary dynamics; and the cultural, social, behavioral, and economic dimensions of pathogen transmission and disease. Research may be on zoonotic, environmentally-borne, vector-borne, enteric, or respiratory pathogens of either terrestrial or aquatic systems and organisms, including diseases of animals and plants, at any scale from specific pathogens to inclusive environmental systems. Proposals for research on disease systems of public health concern to Low- or Middle-Income Countries (LMICs) are strongly encouraged, as are disease systems of concern in agricultural systems. Investigators are encouraged to develop the appropriate multidisciplinary team, including for example, anthropologists, modelers, ecologists, bioinformaticians, genomics researchers, social scientists, economists, oceanographers, mathematical scientists, behaviorists, epidemiologists, evolutionary biologists, entomologists, immunologists, parasitologists, microbiologists, bacteriologists, virologists, pathologists or veterinarians, with the goal of integrating knowledge across disciplines to enhance our ability to predict and control infectious diseases.


Deadline: November 16, 2022

Agency Website

Eligibility Requirements

In a given year, an individual may participate as a PI, co-PI, or subaward lead on no more than two proposals submitted in response to this solicitation. This limit does not include Research Coordination Networks (RCN) proposals. In addition, an individual from Israel may participate in no more than one US-BSF proposal and an individual from China may participate in no more than one US-China proposal. Proposals in excess of the limit for any person will be returned without review in the reverse order received. Participating in a proposal as other senior personnel does not count in this limit. Changes in investigator roles post-submission to meet the eligibility limits will not be allowed. It is the responsibility of the submitters to confirm that the entire team is within the eligibility guidelines.

Amount Description

Estimated Number of Awards: 12

Anticipated Funding Amount: $36,500,000

in FY 2023, pending the availability of funds. That amount includes approximately $15.0M from NSF for new standard or continuing awards, approximately $7.5M from NIH for new or continuing awards, and $14.0M from NIFA for new awards. The expected funding from UKRI for the UK component of the US-UK Collaborative Projects will be a maximum of £3.0M. The expected funding from the BSF for the Israeli component of the US-Israel Collaborative Projects will be a maximum of $720,000. The expected funding from the NSFC for the Chinese component of the US-China Collaborative Projects will be a maximum of ¥9M.

Funding Type





Environmental & Life Sciences
International Opportunities
Medical - Basic Science
Medical - Clinical Science
Social Sciences

External Deadline

November 16, 2022