Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) invites grant applications for Environmental Health Sciences Core Centers (EHS CC). As intellectual hubs for environmental health science research, the EHS CC is expected to be the thought leaders for the field and advance the goals of the NIEHS Strategic Plan (http://www.niehs.nih.gov/about/strategicplan/). The Core Centers provide critical research infrastructure, shared facilities, services and/or resources, to groups of investigators conducting environmental health sciences research. An EHS CC enables researchers to conduct their independently-funded individual and/or collaborative research projects more efficiently and/or more effectively. The overall goal of an EHS CC is to identify and capitalize on emerging issues that advance understanding of the relationships among environmental exposures, human biology, and disease. The EHS CC supports community engagement and translational research as key approaches to improving public health.

Only one application per Institution is allowed.


  • Duke Internal: Interested applicants from within Duke should contact fundopps@duke.edu as early as possible.
  • Letter of Intent Due Date: March 19, 2023; March 19, 2024
  • Application Due Date(s): April 19, 2023; April 19, 2024

RFA-ES-22-010 Expiration Date April 20, 2024

Agency Website

Eligibility Requirements

To be eligible for an EHS CC award, the applicant institution must demonstrate that they have a minimum of six active NIEHS-supported research awards from four distinct PDs/PIs who are members of the proposed Center. At the time of submission of an application, the qualifying awards must have at least 1 full active year remaining.

Acceptable support includes R00, R01, R03, R21, R24, R33, R35, R43, R44, P01, P42, P50, U01, U19, U24, U2C, UG3 and or Research Career Development Awards (K-grants). Multi-component (e.g. P01, P50, or U19) awards only count as one qualifying research project (i.e., sub-components are not separately counted).

T-awards, U45, and Conference awards (R13, U13) do not count towards this requirement. Furthermore, grants and cooperative agreements in extension periods, either with or without additional funds, as well as supplements of any kind, do not count toward this requirement.

      Amount Description

      New or first-time applicants are limited to $850,000 Direct Costs per year. Renewal applications are limited to $1.0M Direct Costs per year. See Eligibility requirements.

      New or first-time applicants may apply for up to 4 years of support. Renewal applications may request up to 5 years of support.

          Funding Type





          Community Outreach and Engagement
          Curriculum Development
          Environmental & Life Sciences
          Medical - Basic Science
          Medical - Clinical Science
          Medical - Translational
          Social Sciences

          External Deadline

          April 19, 2023