Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R01, R21 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this funding opportunity announcement (FOA) is to stimulate research to understand the biological basis by which environmental exposures alter brain and behavioral functioning to increase risk for psychiatric disorders with onset in late-childhood, adolescence or early adulthood. A range of approaches are encouraged, from mechanistic experiments using whole organism models or in vitro and in vivo systems to human studies that add new data collection activities and/or make use of extant data or biospecimens. Investigations that further advance our understanding of the joint contribution of genes and environment in the risk for psychiatric disorders are welcomed. Applications should address either categorically defined psychiatric diagnoses and/or continuous traits expressed in the general population. Applicants are encouraged to propose studies that consider co-occurring psychiatric conditions and potential shared etiologies. It is anticipated that knowledge gained from the research supported by this FOA will inform the development of improved intervention, prevention and/or therapeutic strategies.

This FOA will use the NIH Research Project Grant (R01) award mechanism and runs in parallel with another FOA, PAR-19-385  , which encourages applications under the R21 mechanism.

Application Due Dates: December 10, 2019; November 16, 2020; November 16, 2021

PA-19-386 Expiration Date November 17, 2021

Agency Website



Amount Description

Application budgets are limited to $400,000 direct cost per year and should reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Funding Type





Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

November 16, 2021