The purpose of this Funding Opportunity Announcement (FOA) is to support studies on the epigenetic mechanisms regulating HIV Central Nervous System (CNS) latency and/or neuropathogenesis using in-vitro (macrophages, microglia and astrocytes, organoids), ex-vivo (post-mortem tissues) and in-vivo systems (animal models). Strategies to target epigenetic pathways for achieving sustained HIV remission and treatment of HIV associated-CNS dysfunction are encouraged. The use novel single cell technologies are also strongly encouraged but is not a requirement. Basic and translational research in domestic and international settings are of interest. Multidisciplinary research teams and collaborations are encouraged but not required. High risk/high payoff projects that lack preliminary data may be most appropriate for the companion R21 FOA, RFA-MH-22-281 while applicants with preliminary data may wish to apply using the R01 mechanism.
Deadlines:
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Letter of Intent Due Date(s): 30 days prior to the application due date.
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AIDS Due Date: Dec. 5, 2022
RFA-MH-22-280 Expiration Date December 06, 2022