Gene-Environment Interplay in Substance Use Disorders (R01, R03, R21)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) seeks to stimulate and expand research on the interplay of genetic and environmental factors in the genesis, course, and outcomes of substance and alcohol use disorders (SUDs). Previous work in genetic epidemiology and molecular genetics has established that SUDs are highly heritable, developmental disorders with important genetic substrates.  Building on these findings, new studies using genetically informative approaches are needed to elucidate the complex interplay of genetic and environmental factors in developmental trajectories of SUDs and comorbid conditions, deepen and refine phenotypic definitions of SUDs, and meet the methodologic challenges of the field.  Such studies hold great potential to promote understanding of the true contributions of both genetic and environmental factors to initiation, progression, comorbidity, adverse outcomes, and cessation of SUDs; to elucidate mechanisms of risk; and to enhance opportunities for translation to treatment, prevention, gene-finding and molecular studies.
    

This FOA will utilize the R01 grant mechanism, and runs in parallel with two FOAs of identical scientific scope:  PA-15-112, for exploratory/developmental (R21) grants, and PA-15-111, for R03 small grants.

Deadlines:

  • R01 Deadlines: Feb. 5, Jun. 5, Oct. 5.
  • R03 and R21 Deadlines: Feb. 16, Jun. 16, Oct. 16.
  • AIDS Deadlines: Jan. 7, May 7, Sep. 7.

PA-15-110 Expiration Date New Date January 8, 2018 per issuance of NOT-DA-17-038. (Original Expiration Date: September 8, 2017)

Eligibility

Faculty

Category

Environmental & Life Sciences
Medical
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

October 5, 2017