From Genomic Association to Causation: A Convergent Neuroscience Approach for Integrating Levels of Analysis to Delineate Brain Function in Neuropsychiatry (R01)

Funding Agency:
National Institutes of Health

 The primary objective of this FOA is to stimulate innovative Convergent Neuroscience (CN) approaches to establish causal and/or probabilistic linkages across contiguous levels of analysis (e.g., gene, molecule, cell, circuit, system, behavior) in an explanatory model of psychopathology. In particular, applicants should focus on how specific constituent biological processes at one level of analysis contribute to quantifiable properties at other levels, either directly or as emergent phenomena.  Although not required, it is preferable that applications link at least three levels of analysis and include an emphasis on genetics. The projects under this FOA will develop novel methods, theories, and approaches through a CN team framework, bringing together highly synergistic inter/transdisciplinary teams from neuroscience and the orthogonal fields of the physical sciences (e.g., data/computational science, physics, engineering, mathematics). Successful teams will combine, expand upon, or develop conceptual frameworks and theoretical approaches, and build explanatory computational models that connect contiguous levels of analysis. Such frameworks, theories, and computational explanatory models should be validated through experimental approaches to elucidate biological underpinnings of complex behavioral (including cognitive and affective) outcomes in psychopathology. Additionally, a goal of this program is to advance research in CN by creating a shared community framework of resources which may be used by the broader research community to further research, as such, a successful team will be expected to have a robust plan for sharing data and other resources.

This FOA should be used for applications that are not collaborative between sites. Applications requiring two or more collaborating sites to complete the proposed research should apply as a linked set of collaborative R01 applications to the companion collaborative R01 FOA (PAR-17-252).


  • Letter of Intent Due Date: 30 days prior to the application due date
  • R01 Due Dates: Feb. 5, Jun. 5, Oct. 5

PAR-17-253 Expiration Date September 8, 2020

Agency Website

Eligibility Requirements

Multiple PDs/PIs are required.

Due to the transdisciplinary nature of the projects and the focus on collaboration and expertise sharing, this FOA requires the applicants to comprise a diverse transdisciplinary team of investigators with expertise in the orthogonal fields of physical sciences including mathematics, physics and computational sciences, as well as neuroscience, neuropsychiatry, and other areas of the biological sciences. Successful MPI applications MUST have at least one PD/PI with formal training and expertise in the orthogonal fields of the physical sciences (e.g., data/computational science, physics, engineering, mathematics) and one PD/PI with synergistic expertise in neuroscience/neuropsychiatry.

Formal training and expertise can be established through undergraduate or graduate degrees or successful track record in that field that demonstrates impact on the field.  



Amount Description

Application budgets may not exceed $500,000 direct cost annually for all applications combined in a collaborative set and are expected to reflect actual needs of the proposed project

The maximum project period is 5 years.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

June 5, 2020