HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders: Coordination Center (R24 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The National Institutes of Health (NIH) intends to establish a Harm Reduction Network consisting of several research projects, which will be supported by a single Coordination Center. The goal of this network is to increase our understanding of the effectiveness, implementation, and impact of existing and new harm reduction practices to address the ongoing opioid crisis and substance use disorder more broadly.

This FOA seeks applications for a single Coordination Center for the Harm Reduction network. Key activities for the Coordination Center would include (1) providing logistical and coordination support for the network; (2) providing data harmonization and data sharing supports; (3) convening key stakeholders, (4) developing research and clinical practice resources, including facilitating the development of common metrics defining effective harm reduction, with input from the network, conducting landscape analyses and other research to determine the evolution of harm reduction practices nationally, and developing translational products and tools based on findings from studies funded under this initiative. This FOA runs in parallel with a companion FOA that seeks applications to develop evidence-based harm reduction strategies (RFA-DA-22-046).


  • Letter of Intent Due Date(s): Feb. 10, 2022

  • Application: March 10, 2022

RFA-DA-22-042 Expiration Date March 11, 2022

Agency Website



Amount Description

Application budgets are limited to $500,000 per year in direct costs. Facilities and administrative costs requested by consortium participants are not included in the direct cost limitation.

The project period is 5 years.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

March 10, 2022