HEAL Initiative: Stimulating Peripheral Activity to Relieve Conditions (SPARC): Anatomical and Functional Mapping of Pain-Related Visceral Organ Neural Circuitry (U01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this NIH Funding Opportunity Announcement (FOA) is to invite research applications proposing to map neural circuitry mediating visceral organ pain. This FOA is part of the Stimulating Peripheral Activity to Relieve Conditions (SPARC) Common Fund program and is coordinated with the Translational Devices to Treat Pain (TDTP) initiatives of the NIH HEAL program (see Companion Funding Opportunities above). Detailed mapping of pain-mediating circuitry originating from visceral organ afferents will leverage the SPARC program to produce maps that could accelerate the development of non-addictive approaches to treat pain.

Companion FOAs:

RFA-NS-19-017, U44 Small Business Innovation Research (SBIR) Cooperative Agreements
RFA-NS-19-016, UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement
RFA-NS-19-018, UH3 Exploratory/Developmental Cooperative Agreement Phase II 
RFA-EB-18-003, U18 Research Demonstration – Cooperative Agreements


  • Letter of Intent Due Date(s): 30 days prior to receipt date
  • Application Due Date(s): February 8, 2019

RFA-RM-19-001 Expiration Date February 9, 2019

Agency Website



Amount Description

Application budgets are not limited but need to reflect the actual needs of the proposed project. Budgets should rarely exceed $500,000 direct costs per year.
The maximum budget period is 3 years (FY 2019-2021).

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

February 8, 2019