High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of the High Impact, Interdisciplinary Science grants program is to support high impact ideas that may lay the foundation for new fields of investigation within the mission of NIDDK.  The interdisciplinary approach encouraged by this FOA is envisioned to generate a research resource and/or foster discovery-based or hypothesis-generating science that can have a significant impact on the broader scientific community. This FOA seeks novel approaches in areas that address specific knowledge gaps, scientific opportunities, new technologies, data generation, or research methods that will advance the area in significant ways designed to accelerate scientific progress in the understanding, treatment, and prevention of diseases within the mission of the NIDDK.


  • Letter of Intent Due Date(s): Six weeks prior to the application due date
  • Application Due Date(s): June 1, 2022; Nov 2, 2022; June 1, 2023; Nov 2, 2023; May 30, 2024; Oct. 30, 2024

​PAR-22-069 Expiration Date October 31, 2024

Agency Website

Amount Description

The total annual cost for individual awards is expected to vary, depending on the scope of the project and the number of participating institutions. Application budgets are not limited but need to reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period.

The maximum project period is 5 years. The number of renewals is not fixed; however, as it is anticipated that the underlying science will change over time, the maximum total funding period for any RC2 award is 10 years.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

May 30, 2024