Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This FOA invites new applications to participate in the Human Islet Research Network-Consortium on Human Islet Biomimetics (HIRN-CHIB). NIDDK will support the development of a microphysiological system (MPS) that allows the study of interactions between primary human islets or assembled islet spheroids (organoids made up of human beta/alpha/delta/other cells) and immune cells within a 3D microenvironment to mimic aspects of the autoimmune process and its regulation. The ultimate goal will be to create an in vitro human disease model(s) that could recapitulate some aspects of the complex pathophysiology of Type 1 diabetes (T1D), by using T1D patient-derived islets (created using induced pluripotent stem cells (iPSCs) combined with autologous immune components.  CHIB is already part of HIRN, whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. 


  • Letter of Intent Due Date(s): November 11, 2018
  • Application Due Date(s): December 11, 2018​

RFA-DK-18-011 Expiration Date December 12, 2018

Agency Website

Amount Description

Application budgets are limited to $750,000 direct costs per year for both the UG3 and UH3 phases.
The maximum project period is 5 years, contingent on completion of milestones and research objectives, including a maximum of a 2 year UG3 phase and a maximum of a 3 year UH3 phase.

Funding Type





Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

December 11, 2018