Identification of Positive Valence System Related Targets for Novel Suicide Prevention Approaches (R01, R21 - Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) solicits applications for research projects that will advance translational research to better understand risk and resilience for suicide in the context of the NIMH Research Domain Criteria (RDoC) framework, specifically the Positive Valence Systems (PVS) domain, and lead to novel interventions. The projects should focus on the identification of novel behavioral or neurobiological intervention targets for the treatment of suicidality. NIMH is particularly interested in the role of PVS deficits in suicidal thoughts and behaviors, identification of unique subtypes by behavior and neural circuitry, and associations between PVS-related subtypes and other RDoC domains in relation to suicidality.

Applicants seeking funding for exploratory, smaller scope, highly-innovative projects should consider the companion FOA for R21 applications, PAS-21-215.


  • Letter of Intent: 30 days before the application due date
  • R01 Due Date: Oct. 5, 2021
  • R21 Due Date: Oct. 16, 2021

PAS-21-216 Expiration Date October 06, 2021




Medical - Basic Science
Medical - Clinical Science

External Deadline

October 5, 2021