Immune Development in Early Life (IDEaL) (U01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement is to support research to define the mechanisms regulating the establishment, development and maintenance of immunity throughout childhood (from birth to less than 18 years of age), including the impact of pathogenic or commensal microbes or vaccination against infectious diseases, allergens or environmental pollutants on immune ontogeny and function. This program will establish collaborations among immunologists, neonatologists, pediatricians, systems biologists, and microbiologists to expand our knowledge of the developing immune system. Knowledge obtained through this program may be applied to the design of improved vaccines and immunotherapies to combat infections or treat/prevent immune-mediated diseases in this vulnerable population.

Companion FOA: RFA-AI-20-078 - Immune Development in Early Life (IDEaL) (U19 Clinical Trial Not Allowed)


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): New Date June 18, 2021 as per NOT-AI-21-048
  • AIDS Application Due Date(s): New Date June 18, 2021 as per NOT-AI-21-048

RFA-AI-20-077 Expiration Date New Date June 19, 2021 per issuance of NOT-AI-21-048. (Original Expiration Date: June 05, 2021 )

Agency Website

Eligibility Requirements

An individual may serve as PD/PI on a single PD/PI application or a PD/PI on a multi-PDs/PIs application on either an IDEaL U19 or U01 application, but not both. PDs/PIs may serve as Project leaders, Core leaders or collaborators on an application where they are not the PD/PI on a single PD/PI application or a PD/PI within a multiple PDs/PIs application.



Amount Description

Application budgets are limited to $500,000 in direct costs per year and must reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Funding Type





Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

June 18, 2021