Sponsor Deadline
Posted: 3/14/2024

Impacts of climate change across the cancer control continuum (R01, R21 Clinical Trial Optional)

This notice of funding opportunity (NOFO) aims to support innovative research relevant to advancing the understanding of the effects of climate change across the cancer control continuum, from cancer etiology and cancer risks through survivorship, and ways to prevent or mitigate negative health effects. This includes, but is not limited to, studies to improve knowledge of the impact of climate change related environmental effects on cancer risks, control and behaviors.

Whereas this NOFO is for well-developed projects supported with preliminary data, a companion NOFO (PAR-23-152) of identical scientific scope is meant for R21 pilot/exploratory projects.


  • Letter of Intent Due Date(s): 30 days prior to application due date.

  • R01 Due Dates: Feb. 5, Jun. 5, Oct. 5

  • R21 Due Dates: Feb. 16, Jun. 16, Oct 16

PAR-23-153 Expiration Date May 08, 2026

Areas of Interest

Research topics of specific interest include, but are not limited to the following: 

  • Assess the impact of climate change-related environmental changes on cancer risk and cancer outcomes, including carcinogenic exposures and vector-borne diseases.
  • Understand and address the susceptibility of cancer survivors to direct and/or indirect climate change effects, such as the spread of vector-borne disease, disruptions in care, and factors that can impact cancer recurrence and/or potential latent effects among childhood cancer survivors.
  • Model the magnitude of the impacts of climate change on cancer-related risk factors and health behaviors (e.g. geospatial data linkages).
  • Identify and/or characterize communities particularly vulnerable to increased environmental exposures and cancer risk due to climate change-related events and develop interventions to mitigate the impact of social determinants related to climate change and cancer risk.
  • Develop and test strategies to enhance the equitable adoption, implementation, and sustainability of evidence-based mitigation or adaptation efforts that reduce the burden of climate change on cancer outcomes.
  • Improve understanding of the behavioral, social, and psychological factors that underlie cancer preventive health behaviors implicated in climate change in order to develop approaches to target health behaviors related to both cancer and climate change (e.g., promoting plant-based diets, active transportation).
  • Identify, develop, and test behavioral interventions at multiple levels (from the individual to systems-level) to facilitate behavioral strategies and policies that reduce climate change and promote climate-resilient and adaptive health behaviors.
  • Determine factors (e.g., staffing, infrastructure, technology, supply chains, processes of care) that influence the resiliency of healthcare organizations and their ability to prepare and respond to climate-related events to prevent disruption of cancer care across the cancer control continuum.
  • Identify, develop, and test strategies to enhance health care system climate-resilience and capacity to deliver high-quality, equitable cancer care, particularly in the face of multiple or compounding climate-related events.