Sponsor Deadline
Posted: 3/14/2024

Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research -- 2024 Standing PFA

The Patient-Centered Outcomes Research Institute (PCORI) intends to release a PCORI Funding Announcement (PFA) on May 7, 2024, seeking to fund studies that address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER). This preannouncement is provided to allow potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality proposals.

PCORI seeks to fund projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies.



Deadline for Required Letter of Intent: 

Cycle 1: Feb. 6, 2024
Cycle 2: June 4, 2024
Cycle 3: Oct. 1, 2024

Areas of Interest

For the 2024 Methods PFA, PCORI has identified the following areas as program priorities:   

  • Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Clinical Research  
  • Methods to Improve Study Design   
  • Methods to Support Data Research Networks   
  • Methods Related to Ethical and Human Subjects Protections Issues in CER  
Eligibility Requirements

Applications may be submitted by any private sector research organization, including any nonprofit or for-profit organization, and any public sector research organization, including any university or college hospital or healthcare system, laboratory or manufacturer, or unit of local, state, or federal government. The Internal Revenue Service must recognize all US applicant organizations. Nondomestic components of organizations based in the US and foreign organizations may apply, as long as there is demonstrable benefit to the US healthcare system and US efforts in the area of patient-centered research can be clearly shown. Organizations may submit multiple applications for funding. Individuals are not permitted to apply. 

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