Sponsor Deadline
Posted: 4/2/2024

Informatics Tools for the Pangenome (U01 Clinical Trial Not Allowed)

This NOFO seeks applications for the development of informatics tools to facilitate uptake and scientific use of the human pangenome reference being developed and maintained by the NHGRI Human Genome Reference Program (HGRP).  Emphasis for this RFA will be on development of tools to advance compelling use cases that are relevant to different broad sectors of the genomics community, e.g., clinical, population, and functional genomics. These tools will use pangenome datasets and build on systems developed by the Human Pangenome Coordinating Center (see below), which will support general computational infrastructure for pangenome use. 

This informatics tools RFA will fund one component of an overall HGRP, which will also include two other components: High Quality Reference Genomes (herein called “Genomes Center”), and a Human Pangenome Coordinating Center (Herein called “Coordinating Center”). (See Companion Funding Opportunities). Awardees under all three RFAs will work collaboratively within a consortium towards production and community adoption of the human pangenome reference.   


  • Letter of Intent Due Date(s): October 01, 2023; February 3, 2025

  • Application Due Dates: November 1, 2023; March 3, 2025

RFA-HG-23-026 Expiration Date March 04, 2025

Areas of Interest

Based on the subsequent Concept for this program presented to the National Advisory Council on Human Genome Research the components of the renewal will be:  

  1. High Quality Reference Genomes (“Genomes Center,” see RFA-HG-23-024), a limited competition NOFO that focuses on generating high-quality human genome sequence data and assemblies to fill gaps in genetic variation and diversity, and includes the embedded ELSI component;
  2. Human Pangenome Coordinating Center (“Coordinating Center,” see RFA-HG-23-025), a limited competition NOFO that will serve as the logistic and scientific coordinating center for the HGRP and will create, improve, release, and maintain new pangenome reference versions and organize community outreach and resource adoption;
  3. Informatics Tools for the Pangenome (“Tools Projects,” this NOFO: RFA-HG-23-026), consistent with the overall emphasis of the renewed program on utility and adoption, this NOFO is an open competition that will fund multiple investigators to develop computational tools to address the need to facilitate uptake and use of the pangenome reference with an emphasis on tools for common use cases of the pangenome relevant to broad sectors of the genomics community.

All awardees of the program are expected to work together closely to achieve the goals of HGRP.

In addition to these three NOFOs. NHGRI will encourage investigator-initiated applications on topics related to the development of the pangenome.  

Amount Description

Application budgets are limited to $400,000 direct costs per year, but need to reflect the actual needs of the proposed project.

The maximum project period is 3 years.