Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01, R21, U01)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA), encourages research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors relevant to human populations. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts. These projects should explore the basic aspects of adducts/adductomics that may have a potential utility in cancer detection, cancer prevention, and/or assessing cancer risks. The projects should be relevant to adducts in humans and human populations but may be conducted using various model systems (e.g., cultured cells, animals, etc.). The use of human biospecimens is encouraged and expected if appropriate but not required. In well-justified cases, innovative studies using the adductomic approaches in the context of cancer etiology and/or gene-environment interaction research may also be appropriate. NIEHS may support projects with a focus on innovative technology and method development.  

This FOA is intended for well-developed projects based on strong preliminary data. For exploratory pilot projects of similar scientific scope, prospective applicants are advised to consider the R21 companion FOA (PAR-18-703).  Both FOAs will support basic, discovery-oriented research.  Both FOAs will support basic, discovery-oriented research.
For clinically-relevant translational and/or epidemiological projects exploring adducts/adductomic approaches and markers in human populations (with a comprehensive use of human biospecimens for which detailed medical data are available) potential applicants should consider a third FOA  PAR-15-307 that uses the U01 funding mechanism.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): July 11, 2018

​PAR-18-704 Expiration Date July 12, 2018




Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

July 11, 2018