Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R21 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) solicits grant applications proposing exploratory research projects focused on the early-stage development of highly innovative technologies that improve the quality of the samples used for cancer research or clinical care. This includes new capabilities to address issues related to pre-analytical degradation of targeted analytes during the collection, processing, handling, and/or storage of cancer-relevant biospecimens. The overall goal is to support the development of highly innovative technologies capable of maximizing or otherwise interrogating the quality and utility of biological samples used for downstream analyses. This FOA will support the development of tools, devices, instrumentation, and associated methods to preserve or protect sample integrity, or establish verification criteria for quality assessment/quality control and handling under diverse conditions. These technologies are expected to accelerate and/or enhance research in cancer biology, early detection, and screening, clinical diagnosis, treatment, epidemiology, or address issues associated with cancer health disparities, by reducing pre-analytical variations that affect biospecimen sample quality. Projects proposing application of existing technologies where the novelty resides in the biological or clinical target/question being pursued are not responsive to this solicitation and will not be reviewed.

This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

Deadlines:

  • Letters of Intent Receipt Date(s): 30 days before the application due date
  • Application Due Date(s): February 22, 2021; May 27, 2021; September 29, 2021

RFA-CA-21-005 Expiration Date: September 30, 2021

Agency Website

Areas of Interest

The current issuance of the IMAT Program consists of four separate FOAs that cover the following two areas

  • Molecular and Cellular Analysis Technology Development for Cancer Research is intended to support the development of technologies that are novel and potentially transformative to the molecular and cellular analysis of cancer, which may, in turn, accelerate basic or clinical cancer research. Applications must offer novel measurement, probing, or targeting of cancer-relevant targets at the molecular or cellular level.

    • RFA-CA-21-003 (R21): Supports an early-stage feasibility study (inception through preliminary development) to demonstrate the core functional capabilities of the proposed technology.
    • RFA-CA-21-004 (R33): Assumes completion of the initial phase of development and supports the advanced development and robust validation of the technology
  • Cancer-Relevant Biospecimen Science Technologies is centered on the development and validation of novel technologies to improve or assess the quality of cancer-relevant biospecimens for research or clinical care. Applications must offer novel approaches for procurement, preservation, and/or isolation of proteins, DNA, RNA, and other small molecules from biospecimens or otherwise assess their biological integrity. The emphasis is on reducing the impact of pre-analytical variations in the collection, processing, handling, and preservation of cancer-relevant biospecimens or their derivatives to improve their quality and utility for cancer research or clinical care.
    • RFA-CA-21-005 (this FOA, R21): Supports an early-stage feasibility study (inception through preliminary development) to demonstrate the core functional capabilities of the proposed technology.
    • RFA-CA-21-006 (R33): Assumes completion of the initial phase of development and supports the advanced development and robust validation of the technology.

Amount

$400,000

Amount Description

Direct costs are limited to $400,000 over a 3-year period, with no more than $200,000 in direct costs allowed in any single year.

Application budgets need to reflect the actual needs of the proposed project.

Funding Type

Grant

Eligibility

Faculty

Category

Engineering and Physical Sciences
Interdisciplinary
Medical
Medical - Basic Science
Medical - Clinical Science

External Deadline

September 29, 2021