Interventions for Stigma Reduction to Improve HIV/AIDS Prevention, Treatment and Care in Low- and Middle- Income Countries (R01 - Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this NOFO is to solicit Research Project Grant (R01) applications for up to 3 years of support to develop and test interventions to reduce the impact of HIV-associated stigma on the prevention and treatment of HIV infection and/or AIDS, and on the quality of life of People Living with HIV and/or AIDS (PLWH). The NOFO will also support interventions to address the multiple intersecting stigmas and measurement of the stigmas at individual levels.

Specifically, this initiative will support intervention research on a) novel stigma reduction strategies that link to increase in care-seeking behavior and/or decrease in transmission, b) reducing the impact of stigma on adolescent and/or youth health, c) strategies to cope with the complex burden of stigmatization due to HIV and one or more comorbidities/coinfections, d) reducing the effects of stigma on, and/or by, family members or caregivers of PLWH and e) development of innovative and improved stigma measurement in the context of implementation of a stigma-reduction intervention. The overall goals are to understand how to reduce stigma as a factor in HIV transmission, to eliminate or mitigate the aspects of stigma that limit beneficial health outcomes for the infected and at-risk individuals and communities, and to conduct exploratory studies to determine the feasibility of stigma-reduction interventions related to HIV prevention, treatment and/or care in Low and Middle-Income Countries (LMICs).


  • Letter of Intent Due Date(s): November 20, 2023; November 20, 2024; November 20, 2025
  • AIDS Application Due Date(s): December 20, 2023; December 20, 2024; December 22, 2025

PAR-23-190 Expiration Date December 23, 2025

Agency Website

Eligibility Requirements

Non-domestic entities are restricted to higher education and/or research institutions and other non-profit organizations in LMICs, which are defined by The World Bank as low-, lower-middle-, or upper-middle-income economies - . Hong Kong-based institutions are not eligible as applicant or primary LMIC -partner institutions. If Hong Kong is included, a second institution in mainland China must be involved as the primary collaborating LMIC institution.

Non-U.S. High Income Country Institutions are not eligible as the primary partner for a LMIC Institution, but may be included as consultants, especially if they present special opportunities for the proposed research. LMIC-U.S. or LMIC-LMIC partnerships between institutions are eligible.

This FOA strongly encourages inclusion of women and individuals from groups underrepresented in clinical, biomedical, and socio-behavioral research (including individuals from racial, ethnic, and socially disadvantaged backgrounds and those living with disabilities) as principal investigators/program directors, faculty and scientific collaborators.



    Amount Description

    The combined budget for direct costs for the three-year project period may not exceed $400,000. No more than $200,000 in direct costs may be requested in any single year. The budget request must reflect the actual needs of the proposed project.

      Funding Type



      Women and minorities encouraged


      International Opportunities
      Medical - Basic Science
      Medical - Clinical Science
      Medical - Translational
      Social Sciences

      External Deadline

      December 20, 2023