Sponsor Deadline
Posted: 3/19/2024

Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated fully remotely delivered and conducted clinical trials to assess the efficacy or effectiveness of complementary and integrative health interventions in NCCIH- designated areas of high research priority. Applications submitted under this NOFO are expected to propose a remotely delivered and conducted fully powered clinical trial with no in-person contact between research staff and study participants and may utilize mHealth tools or technologies. Applicants must provide justification for the remotely delivered approach and provide preliminary data on the feasibility and safety of the approach, along with evidence that the intervention has promise of clinical benefit.   

Applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.  

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation.  Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.


  • Letter of Intent Due Date(s): 30 days prior to application due date. 

  • Application Due Dates: Feb. 20, 2024; June 20, 2024; Oct 21, 2024; Feb 20, 2025; June 20, 2025; Oct 20, 2025; Feb 20, 2026; June 22, 2026; Oct 20, 2026

  • AIDS Application Due Dates: March 11, 2024; July 15, 2024; Nov 13, 2024; March 10, 2025; July 15, 2025; Nov 18, 2025; March 17, 2026; July 14, 2026; Nov 17, 2026

PAR-24-086 Expiration Date November 18, 2026

Funding Type