Sponsor Deadline
Posted: 3/19/2024

Leveraging Data at Scale to Understand Natural Product Impacts on Whole Person Health (R01 Clinical Trial Not Allowed)

This notice of funding opportunity (NOFO) will support development, adaptation, and/or applications of computational tools to aggregate and analyze orthogonal chemical and/or biological data sets related to natural products with the aim of generating novel testable hypotheses regarding their biological activity and role in the context of whole person health research.  Projects must leverage and merge multiple compatible or interoperable sources and/or types of data.  Use of artificial intelligence and machine learning approaches is encouraged. This NOFO is part of the Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program. Other components of this Program include the Botanical Dietary Supplements Translational Research Teams (RM1) and RFA-AT-24-007 Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24).

This initiative will support transdisciplinary teams (e.g., data scientists, natural product chemists, nutritionists, clinicians) to adapt, develop and/or deploy computational approaches to generate novel hypotheses regarding the whole person health effects of natural products.  For the purposes of this initiative, whole person health includes assessment of how natural products, either in isolation or combination, shift multiple biological systems toward a healthier phenotype.  Natural products data exists across many different platforms so work may include efforts to aggregate scientific data related to natural products from multiple sources including primary literature, data repositories, electronic health records (EHRs), social media, etc.


  • Letter of Intent Due Date(s): May 28, 2024

  • Application Due Date: June 28, 2024

RFA-AT-24-008 Expiration Date June 29, 2024

Amount Description

Application budgets are limited to less than $500K in Direct Costs but need to reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.