Limited Call for Proposals for HSII Implementation Projects -- Fall 2023

Funding Agency:
Patient-Centered Outcomes Research Institute

The Patient-Centered Outcomes Research Institute (PCORI) intends to release a Limited Call for Proposals for Health Systems Implementation Initiative (HSII) Implementation Projects. The Call for Proposals (CFP) will provide an opportunity for HSII Participants to propose projects that promote the uptake of specific evidence from PCORI-funded comparative clinical effectiveness research within their healthcare delivery settings. Each HSII Participant may propose one project in response to this CFP.  

Interested faculty at Duke should contact Richard Shannon, MD, Senior Vice President and Chief Quality Officer and Medical Officer.


Agency Website

Areas of Interest

Applicants will have the opportunity to propose one of two project types:  

  1. HSII Implementation Projects. These projects will have the goal of broadly integrating evidence into care delivery within the health system’s settings. HSII Implementation Projects should accomplish the desired practice change in ways that are sustainable within the HSII Participant delivery setting and scalable within their system, as relevant. Projects will include rigorous program evaluation that documents the execution of implementation activities, as well as the impact on health and healthcare outcomes.

  2. HSII Pilot Projects. These projects will have the goal of developing and/or refining a proposed implementation approach—i.e., a bundle of implementation strategies—and then piloting the use of the approach by integrating use of the evidence on a small scale. Project evaluation will be designed to demonstrate the feasibility and readiness of that approach, paving the way for a broader effort within the health system once the HSII Pilot Project is complete.  

Eligibility Requirements

  • Eligible HSII Participant Organizations: Health systems that are participating in the Health Systems Implementation Initiative (i.e., that have a fully executed HSII Master Funding Agreement with PCORI for HSII) are eligible to submit a proposal in response to this CFP. 

  • Eligible Principal Investigators: The Principal Investigator must be a Master Funding Agreement (MFA) Project Lead designated in the MFA entered into by the HSII Participant Organization. If proposing a Dual-Principal Investigator structure, at least one Principal Investigator must be a MFA Project Lead designated in the MFA; the other can be another leader, or a second MFA Project Lead (if there are two MFA Project Leads designated in the MFA). 

Funding Type





Medical - Clinical Science
Medical - Translational

External Deadline

November 28, 2023