Sponsor Deadline
Posted: 4/18/2022

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Exploratory Collaborative Innovation Awards (R21 Clinical Trial Optional)

The Clinical and Translational Science Award (CTSA) Program Collaborative Innovation Award (CCIA) supports collaborative research activities that develop innovative solutions that will improve the efficiency, quality and impact of turning laboratory, clinic and community observations into interventions that improve the health of individuals and the public. This funding opportunity announcement (FOA) will support investigators from two or more CTSA Program hub institutions (see below under Eligible Individuals) to either: 1) form new collaborations, or to 2) significantly expand the scientific scope of existing collaborations, or to 3) engage new collaborators in pre- existing collaborations to solve a translational science problem no one hub can solve alone, or disseminate a solution to a translational science problem developed at one hub to other hubs, in so doing testing its robustness to different hub environments and structures and adapting it for further dissemination within outside the CTSA Program consortium if appropriate.


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s):  March 8, 2019, July 11, 2019, November 8, 2019, March 9, 2020, July 10, 2020, November 9, 2020, March 8, 2021, July 9, 2021, November 9, 2021

PAR-19-100 Expiration Date November 10, 2021

Eligibility Requirements

An application must involve investigators who are supported by CTSA Program hub institutions from at least two different and currently funded CTSA Program hubs as of the due date of the application. A CTSA Program hub is defined as a UL1 award with a linked KL2 award and an optional TL1 award. A hub that is in no-cost extension (NCE) status is not considered a currently funded CTSA Program hub (see https://ncats.nih.gov/ctsa/about/hubs). CTSA Program hub institutions include the recipients of the CTSA Program hub award, as well as any institutions listed as partners in the CTSA Program hub UL1 awards.

The PD/PI or contact PD/PI must be employed by and/or recipient of funding from a currently funded CTSA Program hub institution as defined above in Eligible Organizations. Investigators who are not employed by and/or a recipient of funding from a CTSA Program hub institution but who wish to bring an innovative project to the CTSA Program, can co-direct a project in partnership with a contact PD/PI who is employed by a currently funded CTSA Program hub institution using the multiple PD/PI option. 

Amount Description

Application budgets need to reflect the actual needs of the proposed project. The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.    

Funding Type