This is a limited competition. The National Center for Advancing Translational Sciences (NCATS) will award Institutional Research Career Development (K12) programs through the Clinical and Translational Science Awards (CTSA). The purpose of this Notice of Funding Opportunity (NOFO) is to encourage institutions to propose creative and innovative institutional research career development programs designed to prepare an outstanding broadly-experienced pool of promising later stage postdoctoral fellows and junior faculty scholars who have made a commitment to independent clinical and translational science research careers (i.e., tenure-track or equivalent faculty positions) to facilitate their timely career advancement and continued engagement in research (i.e., sectors including academia, industry, nonprofit and government).
This NOFO is part of a required set of companion applications: the Clinical and Translational Science Award (UM1) and companion Institutional Career Development Award (K12). The remaining NOFOs in the suite are optional and include the Ruth L. Kirschstein National Research Service Award (NRSA) institutional training programs (T32 predoctoral and T32 postdoctoral), the Research Education Grant (R25), and the Specialized Innovation Program (RC2). These optional NOFOs are only available to CTSA Program UM1 applicants and award recipients. Applications to the optional NOFOs cannot be awarded until an award has been issued for the UM1. (See Section III. Eligibility Information of this NOFO and the respective NOFOs for more information).
This Notice of Funding Opportunity (NOFO) allows appointment of Scholars (K12) proposing to serve as the lead investigator of an independent clinical trial; or proposing a separate ancillary clinical trial; or proposing to gain research experience in a clinical trial led by another investigator, as part of their research and career development.
Only one application per institution (normally identified by having a unique entity identifier (UEI) or NIH IPF number) is allowed. Interested applicants from within Duke should contact fundopps@duke.edu as early as possible.
Deadlines:
- Letter of Intent Due Date(s): 30 days before the application due date
- Application Due Dates: March 13, 2025; May 28, 2025; Sep 29, 2025; Jan 28, 2026; May 28, 2026; Sep 28, 2026; Jan 28, 2027; May 28, 2027; Sep 28, 2027
PAR-25-196 Expiration Date September 29, 2027
All applicant organizations and/or active award recipients for PAR-24-272 or PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional) are eligible to apply under this NOFO.
Only the primary UM1 CTSA hub organization is eligible to apply. Partner/Partnering and/or Collaborator/Collaborating institutions are not eligible.
The institutional research career development K12 required UM1 companion application must be submitted in accordance with the UM1 and K12 NOFOs application submission dates under the following scenario:
- Initial concurrent submission of both a UM1 application and a K12 application.
The K12 required companion application may be resubmitted in accordance with the applicable NOFO application submission dates under the following scenarios:
- concurrently with the resubmitted UM1
- while the UM1 application is under review consideration
- after the UM1 application is funded
- while the UM1 is under consideration for funding
While the K12 required companion application must be submitted concurrently with the initial UM1 application or resubmitted at any time the submitted UM1 new or resubmission application or award remains active, the K12 required companion application will only be awarded if the UM1 is awarded.
The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program.
The PD/PI should be an established investigator in the scientific area in which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the proposed program. The PD/PI should be an established investigator (successfully competed for an R01 or R01-equivalent research grant) and must demonstrate effective mentoring of individuals at the same career stage as scholars who would be appointed to the award. The PD/PI will be responsible for the selection and appointment of trainees to the approved research training program, and for the overall direction, management, administration, and evaluation of the program. The PD/PI will be expected to monitor and assess the program and submit all documents and reports as required. The PD/PI has responsibility for the day-to-day administration of the program and is responsible for appointing members of the Advisory Committee (when applicable), using their recommendations to determine the appropriate allotment of funds.The UM1 PD(s)/PI(s) may not be a PD(s)/PI(s) on the required companion K12 in order to ensure the PD(s)/PI(s) have adequate time to devote to the respective programs.
This NOFO is part of a required set of companion applications: the Clinical and Translational Science Award (UM1) and companion institutional research career development (K12). The remaining NOFOs in the suite are optional and include the Ruth L. Kirschstein National Research Service Award (NRSA) institutional training programs (T32 predoctoral and T32 postdoctoral), the Research Education Grant (R25), and the Specialized Innovation Program (RC2). These optional NOFOs are only available to CTSA Program UM1 applicants and award recipients. Applications to the optional NOFOs cannot be awarded until an award has been issued for the UM1. Adhering to the submission eligibility below, a set must contain 1 application to the UM1 NOFO and 1 application to this K12 NOFO; it may also contain 1 application to the T32 predoc NOFO, 1 application to T32, postdoc NOFO, 1 application to R25 NOFO, and/or up to 2 applications for the RC2 NOFO.