Sponsor Deadline
Posted: 4/18/2022

Limited Competition: Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection - Coordinating Center (U24 Clinical Trial Not Allowed)

The purpose of this funding opportunity announcement (FOA) is to invite applications for the Coordinating Center (CC) for the NIH Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion, tMCAo). The CC will work with the awarded SPAN testing laboratories (RFA-NS-22-003) and intervention contributors (RFA-NS-22-032, RFA-NS-22-033) to provide centralized administrative oversight and coordination of all aspects of the network. If successful, the SPAN network will accelerate the identification of the most promising cerebroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and-time-effective fashion.

This limited competition FOA solicits applications for the Coordinating Center (CC) for SPAN. Separate FOAs are issued to solicit applications for the testing laboratories (RFA-NS-22-003) and cerebroprotective intervention research projects (RFA-NS-22-032, RFA-NS-22-033).


  • Letter of Intent Due Date(s): 30 days prior to application due date.

  • Application Due Date: March 14, 2022

RFA-NS-22-004 Expiration Date March 15, 2022

Eligibility Requirements

To avoid a conflict of interest, the Institution being awarded a SPAN CC U24 cannot be awarded a testing laboratory (RFA-NS-22-003) or research project/intervention (RFA-NS-22-032, RFA-NS-22-033) U01/U44.

Amount Description

Application budgets may not exceed a maximum of $600,000 in direct costs per year but need to reflect the actual needs of the proposed project.

The maximum project period cannot exceed 3 years, but the actual funded project period is dependent upon reaching specific performance milestones (see Cooperative Agreement Terms and Conditions of Award).

Funding Type