Sponsor Deadline
Posted: 4/19/2023

Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)

The National Institute of Environmental Health Sciences (NIEHS) is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) Centers. SRP Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes research translation), data management and analysis, community engagement, research experience and training coordination, and research support functions.  The scope of the SRP Centers is taken directly from the Superfund Amendments and Reauthorization Act of 1986, and includes: (1) advanced techniques for the detection, assessment, and evaluation of the effect on human health of hazardous substances; (2) methods to assess the risks to human health presented by hazardous substances; (3) methods and technologies to detect hazardous substances in the environment; and (4) basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances.

Only one application per institution is allowed. Duke currently has an SRP Center through 2027 under PI Heather Stapleton.


  • Duke Internal: 
  • Letter of Intent Due Date: Sep. 2, 2023
  • Application Due Date(s): Oct. 2, 2023


RFA-ES-23-001 Expiration Date October 03, 2023

Eligibility Requirements

Per NIEHS legislative authority, ONLY Higher Education Institutions may apply to this P42 NOFO. Section 311(a)(3) of SARA limits recipients of awards to "accredited institutions of higher education," which are defined in the Higher Education Act, 20 USC (annotated) 3381. However, applicants are permitted under the law, and encouraged by NIEHS, to subcontract as appropriate with organizations, domestic or foreign, public or private (such as universities, colleges, hospitals, laboratories, faith-based organizations, units of State and local governments, and eligible agencies of the Federal Government) as necessary to conduct portions of the research. Examples of other organizations may include generators of hazardous wastes; persons involved in the detection, assessment, evaluation, and treatment of hazardous substances; owners and operators of facilities at which hazardous substances are located; and/or State and local governments.

Amount Description

Applications may request a budget for direct costs of up to $2 million dollars for each year.

Applications may propose a project period of up to 5 years.