Long-Term Outcomes of Medically Assisted Reproduction (R01, R21)

Funding Agency:
National Institutes of Health

Assisted Reproductive Technologies (ART) and Non-IVF Fertility Treatments (NIFT) have revolutionized the field of human reproduction for the past 3 decades. Millions of children have been born worldwide through the utilization of these technologies.  An analysis of the long-term outcomes in the children is crucial for understanding the inherent risks or benefits of these procedures.  The outcomes of children conceived after ART include data from nationally-maintained registries in different countries around the world. There is no uniformity in the collection and analysis of data, and most registries lack information on long-term health and developmental outcomes. NIFT has been in use for much longer than ART, and there is lack of national registries for outcomes of NIFT across the world. Long-term biological, physical, and social outcomes of offspring conceived by ART or NIFT may be different depending upon the methods or approaches used in ART or NIFT. The underlying cause of parental infertility may also contribute to the outcomes. This funding opportunity announcement encourages the extramural scientific community to submit applications to study ART and NIFT for their potential long-term health and developmental outcomes. 

Although this funding opportunity uses the R01 grant mechanism, it runs in parallel with a program announcement of identical scientific scope, PAR-14-273, whcih uses the exploratory/developmental (R21) grant mechanism.


  • Letter of Intent Due Date(s): 30 days before application due date
  • Application Due Date(s): September 30, 2014; September 30, 2015; September 30, 2016, by 5:00 PM local time of applicant organization.

PAR-14-272 Expiration Date October 1, 2016




Medical - Basic Science
Medical - Clinical Science
Social Sciences

External Deadline

September 30, 2015